Functional approach to sleep disturbance in chronic fatigue: chronic fatigue and sleep disturbance

Sleep Disturbance in Travelers

Sleep disturbance, cytokines, and fatigue in women with ovarian cancer.

Pro-inflammatory cytokines, such as interleukin-6 (IL-6), have been implicated in the underlying processes contributing to sleep regulation and fatigue. Despite evidence for sleep difficulties, fatigue, and elevations in IL-6 among women with ovarian cancer, the association between these symptoms and IL-6 has not been investigated. To address this knowledge gap, we examined relationships betwee...

SLEEP-WAKE BEHAVIOR IN CHRONIC FATIGUE SYNDROME Sleep-Wake Behavior in Chronic Fatigue Syndrome

671 Sleep-Wake Behavior in CFS—Rahman et al about the mechanisms responsible for the experience of poor quality sleep in CFS. Human sleep is part of an oscillating sleep-wake pattern following a circadian rhythm.8 These cyclical rhythms are directed by the brain’s biological “clock” located in the suprachiasmatic nucleus and cause fluctuation of body temperature, hormone levels, and sleep over ...

Sleep in the chronic fatigue syndrome.

Chronic fatigue syndrome (CFS) is a disabling condition characterized by severe fatigue lasting for more than six months and the presence of at least four out of eight minor criteria. Sleep disturbance presenting as unrefreshing or nonrestorative sleep is one of these criteria and is very common in CFS patients. Biologically disturbed sleep is a known cause of fatigue and could play a role in t...

Chronic sleep disturbance and neural injury: links to neurodegenerative disease.

Sleep-wake disruption is frequently observed and often one of the earliest reported symptoms of many neurodegenerative disorders. This provides insight into the underlying pathophysiology of these disorders, as sleep-wake abnormalities are often accompanied by neurodegenerative or neurotransmitter changes. However, in addition to being a symptom of the underlying neurodegenerative condition, th...